Luteolin（木犀草素，AbMole，M4589）是一种广泛存在于植物中的黄酮类化合物，具有多种生物活性，包括抑制炎症、抗氧化、抑制肿瘤生长以及抗菌等作用。在细胞实验中，Luteolin在20-40 µM浓度范围内显著抑制肺癌A549细胞的迁移、侵袭以及伪足形成，且对非癌性MRC-5细胞无毒性作用[1]。此外，Luteolin（CAS No.：491-70-3）在40 µM浓度下可显著减少HT29细胞的存活率，并通过增加活性氧（ROS）水平诱导细胞凋亡[2]。Luteolin在黑色素瘤研究中，体外细胞模型和体内小鼠模型均表现出抑制肿瘤生长的效果，其作用机制涉及基因组水平的调控[3]。Luteolin在肺癌小鼠模型中，通过增强T细胞介导的杀伤途径促进肿瘤细胞凋亡，显著抑制肿瘤生长[4]。Luteolin在抗菌研究中，对金黄色葡萄球菌（包括耐甲氧西林金黄色葡萄球菌MRSA）表现出抑制作用[5, 6]。在神经保护研究中，Luteolin可显著预防β-淀粉样蛋白（Aβ）诱导的PC-12细胞凋亡，并抑制细胞活力下降[7]。此外，Luteolin在α-葡萄糖苷酶抑制实验中表现出非竞争性抑制机制，其IC50值约为32 µM，显著低于阿卡波糖（815 µM）[8]。Luteolin在昆虫研究中，在0.1 mg/mL浓度下可显著缩短成虫寿命并降低繁殖力[9]。这些研究结果表明，Luteolin（木犀草素，AbMole，M4589）在多种细胞（如A549、HT29、PC-12）和动物模型（如小鼠）中具有广泛的科研应用潜力，其作用机制涉及多种信号通路和分子靶点。
参考文献及鸣谢
1\] Masraksa, W.; Tanasawet, S.; Hutamekalin, P.; et al. Luteolin attenuates migration and invasion of lung cancer cells via suppressing focal adhesion kinase and non-receptor tyrosine kinase signaling pathway. *Nutrition research and practice* **2020** , *14* (2), 127-133. \[2\] Yang, H.; Liu, B. F.; Xie, F. J.; et al. Luteolin induces mitochondrial apoptosis in HT29 cells by inhibiting the Nrf2/ARE signaling pathway. *Experimental and therapeutic medicine* **2020** , *19* (3), 2179-2187. \[3\] Schomberg, J.; Wang, Z.; Farhat, A.; et al. Luteolin inhibits melanoma growth in vitro and in vivo via regulating ECM and oncogenic pathways but not ROS. *Biochemical pharmacology* **2020** , *177*, 114025. \[4\] Li, X.; Bai, Y.; Zhou, J.; et al. Luteolin targets peroxiredoxin 2 to augment T-cell-mediated cytotoxicity and suppress lung adenocarcinoma progression. *European journal of pharmacology* **2025** , *1004*, 177984. \[5\] Sun, Y.; Sun, F.; Feng, W.; et al. Luteolin Inhibits the Biofilm Formation and Cytotoxicity of Methicillin-Resistant Staphylococcus aureus via Decreasing Bacterial Toxin Synthesis. *Evidence-based complementary and alternative medicine : eCAM* **2022** , *2022*, 4476339. \[6\] Zhang, D.; Gao, X.; Song, X.; et al. Luteolin Showed a Resistance Elimination Effect on Gentamicin by Decreasing MATE mRNA Expression in Trueperella pyogenes. *Microbial drug resistance (Larchmont, N.Y.)* **2019** , *25* (4), 619-626. \[7\] Wang, H. R.; Pei, S. Y.; Fan, D. X.; et al. Luteolin Protects Pheochromocytoma (PC-12) Cells against Abeta (25-35)-Induced Cell Apoptosis through the ER/ERK/MAPK Signalling Pathway. *Evidence-based complementary and alternative medicine : eCAM* **2020** , *2020*, 2861978. \[8\] Djeujo, F. M.; Ragazzi, E.; Urettini, M.; et al. Magnolol and Luteolin Inhibition of alpha-Glucosidase Activity: Kinetics and Type of Interaction Detected by In Vitro and In Silico Studies. *Pharmaceuticals (Basel, Switzerland)* **2022** , *15* (2). \[9\] Ren, X.; Li, M.; Zheng, L.; et al. Luteolin Effects on Mortality, Development and Population Parameters of Frankliniella occidentalis (Pergande). *Insects* **2025** , *16* (12).