文章目录
介绍
在本文中，我们提出了一种新的机器学习（ML）管道，用于多基因组学探索，以发现高精度疾病预测中重要的生物标志物。智能是基于一种新颖的方法，它包括传统的统计技术和使用多基因组、临床和人口统计数据的尖端机器学习算法的联系。智能基因引入了一种新的度量，即智能基因（I-Gene）评分来衡量个体生物标志物对复杂性状预测的重要性。I-Gene评分可用于生成个体的I-Gene谱，以理解用于疾病预测的ML的复杂性。智能手机是一个用户友好的、可移植的、跨平台的应用程序，与微软的Windows、macOS和UNIX操作系统兼容。智能不仅具有个性化早期检测个体常见和罕见疾病的潜力，而且还为使用新的ML方法进行更广泛的研究开辟了道路，最终导致个性化干预和新的治疗目标。
Abstract
In this article, we present IntelliGenes, a novel machine learning (ML) pipeline for the multi-genomics exploration to discover biomarkers significant in disease prediction with high accuracy. IntelliGenes is based on a novel approach, which consists of nexus of conventional statistical techniques and cutting-edge ML algorithms using multi-genomic, clinical, and demographic data. IntelliGenes introduces a new metric, i.e. Intelligent Gene (I-Gene) score to measure the importance of individual biomarkers for prediction of complex traits. I-Gene scores can be utilized to generate I-Gene profiles of individuals to comprehend the intricacies of ML used in disease prediction. IntelliGenes is user-friendly, portable, and a cross-platform application, compatible with Microsoft Windows, macOS, and UNIX operating systems. IntelliGenes not only holds the potential for personalized early detection of common and rare diseases in individuals, but also opens avenues for broader research using novel ML methodologies, ultimately leading to personalized interventions and novel treatment targets.
代码
bash
# Clone IntelliGenes' GitHub Repository
git clone https://github.com/drzeeshanahmed/intelligenes.git
# Navigate to IntelliGenes
cd intelligenes/
# Install IntelliGenes
pip install .
案例
bash
# Clone IntelliGenes' GitHub Repository
git clone https://github.com/drzeeshanahmed/intelligenes.git
# Navigate to IntelliGenes
cd intelligenes/
# Install IntelliGenes
pip install .
# Discover Biomarkers
igenes_select -i data/cigt_file.csv -o results/
# Disease Prediction & I-Genes Scores
igenes_predict -i data/cigt_file.csv -f features_file.csv -o results/
# IntelliGenes (Discovering Biomarkers & Predicting Disease)
igenes -i data/cigt_file.csv -o results/参考
- IntelliGenes: a novel machine learning pipeline for biomarker discovery and predictive analysis using multi-genomic profiles